2021 Lexus RX 350

Original MSRP Range
$45,220 - $52,500
Available Style(s)
Sport Utility
19 - 20 MPG City / 26 - 27 MPG Hwy
Find 2021 Lexus RX 350 Vehicles for Sale
1,185 vehicles starting at $45,500
2021 Lexus RX 350

What We Like

  • Exemplary Lexus build quality
  • Comfortable and composed driving experience
  • Efficient hybrid model
  • Standard accident avoidance technology
  • Solid reputation for reliability


Expert Rating

4.4/ 5

Consumer Rating

4.2/ 5


How Much Does a 2021 Lexus RX 350 Cost?

The 2021 Lexus RX premium midsize SUV/crossover comes as the V6-powered RX 350 or the hybrid RX 450h. Whenever the letter L comes at the end, that means it’s a longer version with three rows of seating. Seating in an RXL is for seven, or six if there are two captain’s chairs in the second row. These are optional in the RX 350 L, but standard in the RX 450h L. Without the L suffix, the RX seats five people in two rows. The F Sport is a sportier variant of the 2-row model. Standard features are virtually the same across the range, regardless of the drivetrain or number of seats. All-wheel drive is a $1,400 option for the RX 350 models. The destination charge is $1,025. The basic RX 350 ($45,170) includes 18-in alloy wheels, powered liftgate, automatic LED headlights, automatic high beams, self-dimming/power-folding mirrors, forward collision warning, automatic emergency braking, lane-keeping assistance, adaptive cruise control, blind spot monitoring with rear cross-traffic alert, keyless entry/ignition, dual-zone automatic climate control, 8-way power-adjustable front seats, simulated leather upholstery, power-adjustable leather-wrapped steering wheel, cargo cover, 8-in infotainment touchscreen (also controlled by a center console knob), Bluetooth, two USB ports, 9-speaker audio system with a media player interface, CD player, Apple CarPlay/Android Auto smartphone integration, HD radio, and an auxiliary audio input. The Premium package adds driver’s-side memory settings and wood trim. The Luxury package includes those items, plus 20-in alloy wheels, upgraded leather upholstery, front-seat lumbar adjustment, heated steering wheel, powered moonroof, and rear door sunshades. The RX 450h ($47,820) is equipped much like the 350, but with the gasoline/electric hybrid drivetrain and all-wheel drive as standard. The RX 350 F Sport ($51,050) and RX 450h F Sport ($53,620) add 20-in alloy wheels, adaptive suspension dampers, enhanced engine sounds, paddle shifters for the transmission, specific exterior styling and interior trim, heated/ventilated front sport seats, leather upholstery, extra color choices, and the contents of the Premium package. The Luxury package is not available, nor does the F Sport treatment apply to the L variants. The 2021 RX 350 L ($48,000) and RX 450h L ($51,210) have their own all-wheel drive system and third-row seating as standard, but are otherwise equipped like their standard-length counterparts. A Navigation package is available on every version, bringing a 12.3-in central display, navigation, 12-speaker sound system, and the Remote Touch interface (a joystick-like center console controller). More option choices depend on region, specifically in regard to certain extras that can be available as either individual items and/or within packages. These include hands-free lift gate operation, a choice of sunroofs (regular or panoramic), parking sensors, upgraded headlights, power-folding second-row seat, heated/ventilated front seats, heated steering wheel, wireless charging, head-up display, and a 15-speaker Mark Levinson sound system.

RX 350 Trims

Sport UtilityOriginal MSRP / PriceEngineHorsepowerCity MPG / Hwy MPGTransmissionDrive
RX RX 350 AWD$46,620 / $43,5886 Cylinder29519 / 268-Speed Shiftable AutomaticFWD / AWD4WD
RX RX 350 F SPORT Appearance AWD$50,100 / $46,8446 Cylinder29519 / 268-Speed Shiftable AutomaticFWD / AWD4WD
RX RX 350 F SPORT Appearance FWD$48,700 / $45,5356 Cylinder29520 / 278-Speed Shiftable AutomaticFWD / AWD4WD
RX RX 350 F SPORT Handling AWD$52,500 / $49,0896 Cylinder29519 / 268-Speed Shiftable AutomaticFWD / AWD4WD
RX RX 350 F SPORT Handling FWD$51,100 / $47,7806 Cylinder29520 / 278-Speed Shiftable AutomaticFWD / AWD4WD
RX RX 350 FWD$45,220 / $42,2796 Cylinder29520 / 278-Speed Shiftable AutomaticFWD / AWD4WD
Lexus RX 350 Safety

Is the 2021 Lexus RX 350 a Safe Car?

The RX comes standard with an impressive amount of safety features beyond the mandatory stability control and airbags. Forward collision mitigation with automatic emergency braking, blind spot monitoring with rear cross-traffic alert, lane-keeping assistance and emergency communications are all standard. In crash tests carried out by the National Highway Traffic Safety Administration (NHTSA), the RX earned the best-possible 5-star rating for overall crash protection, including 4-star frontal and 5-star side crash ratings. The Insurance Institute for Highway Safety (IIHS) also gave it the best possible ratings for crash protection and prevention, as well as for its child seat LATCH anchors.
Rollover Rating–Overall
Side Barrier Rating–Overall
Side Crash Rating–Overall
5 Year Cost to Own

$58,042 ($0.77 per mile)

5-Year Cost to Own includes out of pocket expenses like fuel and insurance, plus the cars loss in value over time (depreciation)See Detailed Cost to Own

Original Warranty

Basic4 Years/50,000 Miles
Drivetrain6 Years/70,000 Miles
Corrosion6 Years/Unlimited Miles
Roadside Assistance4 Years/Unlimited Miles
Maintenance1 Years/10,000 Miles

Safety Features & Equipment

Braking & Traction
  • 4-Wheel Anti-Lock Brakes
  • Brake Assist
  • Tire Pressure Monitoring System
  • Traction Control
Passenger Restraint
  • Child Safety Locks
  • Driver Air Bag
  • Passenger Air Bag
  • Rear Body Air Bag
  • Rear Side Curtain Airbags
  • Side Air Bag
  • Side Head Air Bag
Road Visibility
  • Daytime Running Lights
  • Fog Lights
Accident Prevention
  • Bluetooth, Hands-Free
  • Parking assist
  • Rearview Camera
  • Alarm System
  • Telematics
  • Vehicle Anti-Theft System
  • Blind-Spot Monitor
  • Black Line Special Edition
  • Premium Pkg


2021 Lexus RX 350 vs the competition

2021 Acura MDX — The RX’s closest competitor in terms of pricing and reliability reputation. It is 3-row only and available as a hybrid. 2021 Volvo XC90 — The stylish, spacious XC90 can be a fashion statement just as much as a school run machine. Its third row is one of the most accommodating in the class and there’s a plug-in hybrid model. 2021 Acura RDX — Technically, this belongs in the segment below. But the RDX is so refined, well equipped and spacious that it could definitely be compared to the RX. Used BMW X5 — Stronger performance and better handling than the RX, plus the cachet of the BMW badge. But prices are a lot higher, so a used example is more affordable. Check out BMW’s certified pre-owned (CPO) program.

Lexus RX 350 News & Reviews


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