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Spider

Fullsize Regular Cab

Truck

AWD4WD

8-Cylinder

Gasoline

Sierra 2500

1SA Pro Safety Plus Package

Convenience Package

New 2025 GMC Sierra 2500 Pro w/ 1SA Pro Safety Plus Package

New 2025 GMC Sierra 2500 Pro w/ 1SA Pro Safety Plus Package Greenville SC 29607

Automatic

Fullsize Crew Cab

8-Cylinder Turbo

Diesel

X31 Off-Road and Protection Package

SLT Convenience Package

Sierra HD Pro Safety Plus Package

SLT Preferred Package

LPO, Assist Step and Floor Liner Package

New 2025 GMC Sierra 2500 SLT

New 2025 GMC Sierra 2500 SLT Gaffney SC 29341

Used

AT4 Preferred Package

Driver Alert Package I

Get AutoCheck Vehicle History

Used 2022 GMC Sierra 2500 AT4 w/ AT4 Preferred Package

Used 2022 GMC Sierra 2500 AT4 w/ AT4 Preferred Package Shelby NC 28152

Duramax Plus Package

Suspension Package, Off-Road

Used 2016 GMC Sierra 2500 Denali w/ Duramax Plus Package

Used 2016 GMC Sierra 2500 Denali w/ Duramax Plus Package Greenville SC 29607

Denali

New 2025 GMC Sierra 2500 Pro w/ Convenience Package

New 2025 GMC Sierra 2500 Pro w/ Convenience Package Gaffney SC 29341

SLT Premium Package

Gooseneck/5th Wheel Prep Package

Used 2024 GMC Sierra 2500 SLT w/ SLT Premium Package

Used 2024 GMC Sierra 2500 SLT w/ SLT Premium Package Greenville SC 29607

Denali Reserve Package

LPO, Hitch Package

New 2025 GMC Sierra 2500 Denali w/ Denali Reserve Package

New 2025 GMC Sierra 2500 Denali w/ Denali Reserve Package Gaffney SC 29341

SLE Value Package;

Max Trailering Package

New 2025 GMC Sierra 2500 SLE w/ SLE Value Package;

New 2025 GMC Sierra 2500 SLE w/ SLE Value Package; Gaffney SC 29341

Flexible Fuel

Sierra Convenience Package

Used 2019 GMC Sierra 2500 4x4 Double Cab w/ Sierra Convenience Package

Used 2019 GMC Sierra 2500 4x4 Double Cab w/ Sierra Convenience Package Clinton SC 29325

4x4 Double Cab

Used 2022 GMC Sierra 2500 Denali

Used 2022 GMC Sierra 2500 Denali Spartanburg SC 29301

Denali Ultimate Package

LPO, GMC Protection Package

Used 2022 GMC Sierra 2500 Denali w/ Denali Ultimate Package

Used 2022 GMC Sierra 2500 Denali w/ Denali Ultimate Package Greer SC 29651

Used 2024 GMC Sierra 2500 Denali w/ Denali Reserve Package

Used 2024 GMC Sierra 2500 Denali w/ Denali Reserve Package Easley SC 29640

Midsize

Sport Utility

4-Cylinder Turbo

Terrain

License Plate Front Mounting Package

Used 2024 GMC Terrain SLE

Used 2024 GMC Terrain SLE Gaffney SC 29341

All-Terrain HD Package

SLE Preferred Package

Snow Plow Prep Package

Used 2015 GMC Sierra 2500 SLE w/ All-Terrain HD Package

Used 2015 GMC Sierra 2500 SLE w/ All-Terrain HD Package Greer SC 29650

Certified

Technology Package

Certified 2025 GMC Sierra 2500 Denali w/ Max Trailering Package

Certified 2025 GMC Sierra 2500 Denali w/ Max Trailering Package Greenville SC 29607

Used 2023 GMC Sierra 2500 AT4 w/ AT4 Preferred Package

Used 2023 GMC Sierra 2500 AT4 w/ AT4 Preferred Package Shelby NC 28152

Gooseneck/5TH Wheel Package

Heavy Duty Front Spring/Camper Package

Used 2020 GMC Sierra 2500 Denali w/ Denali Ultimate Package

Used 2020 GMC Sierra 2500 Denali w/ Denali Ultimate Package Moore SC 29369

Used 2020 GMC Sierra 2500 Denali w/ Denali Ultimate Package Greenville SC 29607

Used 2024 GMC Sierra 2500 Denali w/ Denali Reserve Package Greenville SC 29607

Used 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package

Used 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package Hendersonville NC 28792

Driver Alert Package

Used 2015 GMC Sierra 2500 SLT w/ Driver Alert Package

Used 2015 GMC Sierra 2500 SLT w/ Driver Alert Package Greer SC 29651

Certified 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package

Certified 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package Clover SC 29710

LPO, Denali Illumination Package

Used 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package Greenville SC 29607

AT4 Premium Plus Package

Used 2025 GMC Sierra 2500 AT4 w/ AT4 Premium Plus Package

Used 2025 GMC Sierra 2500 AT4 w/ AT4 Premium Plus Package Gaffney SC 29341

Used 2015 GMC Sierra 2500 Denali w/ Duramax Plus Package

Used 2015 GMC Sierra 2500 Denali w/ Duramax Plus Package Greenville SC 29607

Used 2022 GMC Sierra 2500 AT4 w/ Gooseneck/5TH Wheel Package

Used 2022 GMC Sierra 2500 AT4 w/ Gooseneck/5TH Wheel Package Greenville SC 29607

New 2026 GMC Sierra 2500 Denali Ultimate

New 2026 GMC Sierra 2500 Denali Ultimate Spruce Pine NC 28777

Denali Ultimate

Used 2019 GMC Sierra 2500 Denali w/ Duramax Plus Package

Used 2019 GMC Sierra 2500 Denali w/ Duramax Plus Package Greenville SC 29607

Used 2024 GMC Sierra 2500 Denali Ultimate w/ Max Trailering Package

Used 2024 GMC Sierra 2500 Denali Ultimate w/ Max Trailering Package Greer SC 29651

Used 2015 GMC Sierra 2500 HD Crew Cab SLT Pickup 4D 6 1/2 ft

Used 2015 GMC Sierra 2500 SLT w/ Duramax Plus Package

Used 2015 GMC Sierra 2500 SLT w/ Duramax Plus Package Anderson SC 29621

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Greenville - Spart - Asheville

Used Cars for Sale

Test drive Used GMC Sierra 2500 at home in Spartanburg, SC. Search from 24 Used GMC Sierra 2500 cars for sale, including a  2015 GMC Sierra 2500 Denali, a  2015 GMC Sierra 2500 SLE, and a  2015 GMC Sierra 2500 SLT ranging in price from $20,500 to $83,990.

Used GMC Sierra 2500 for Sale in Spartanburg, SC - Autotrader

The GMC Sierra 2500 is an intriguing mix of heavy-hitting workhorse and glitzy luxury. With powerful <a href="https://www.autotrader.com/cars-for-sale/diesel/gmc/sierra-2500" target="_blank">diesel</a> or <a href="https://www.autotrader.com/cars-for-sale/gasoline/gmc/sierra-2500" target="_blank">gasoline</a> powertrain options, the Sierra 2500 has immense towing and hauling capacity. The 2500 has well-mannered on-road handling and is equally at home on a dirt ranch road.  The configurations with the Sierra 2500 are nearly endless, with multiple cab sizes, bed lengths, and an array of powertrain choices. Some of the popular Sierra 2500 trims include the <a href="https://www.autotrader.com/cars-for-sale/gmc/sierra-2500/at4" target="_blank">AT4</a>, <a href="https://www.autotrader.com/cars-for-sale/gmc/sierra-2500/denali" target="_blank">Denali</a>, <a href="https://www.autotrader.com/cars-for-sale/gmc/sierra-2500/denali-ultimate" target="_blank">Denali Ultimate</a>, <a href="https://www.autotrader.com/cars-for-sale/gmc/sierra-2500/sle" target="_blank">SLE</a>, and <a href="https://www.autotrader.com/cars-for-sale/gmc/sierra-2500/slt" target="_blank">SLT</a>. Even with fierce competition in the heavy-duty pickup segment, the GMC Sierra 2500 still makes waves. With powerful towing capabilities, a luxurious interior, and refined on-road driving, the Sierra 2500 is a rewarding heavy-duty truck.  

Used GMC Sierra 2500 for Sale Under $30,000

Used GMC Sierra 2500 for Sale Under $20,000

Used GMC Sierra 2500 for Sale Under $15,000

Used GMC Sierra 2500 for Sale Under $5,000

Used GMC Sierra 2500 for Sale Under $25,000

Used GMC Sierra 2500 for Sale Under $10,000

Search from 24 GMC Sierra 2500 for sale, including a Certified 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package, a Certified 2025 GMC Sierra 2500 Denali w/ Max Trailering Package, and a Used 2015 GMC Sierra 2500 Denali w/ Duramax Plus Package ranging in price from $20,500 to $83,990.

Autotrader has 24 GMC Sierra 2500 for sale near Spartanburg, SC, including a Certified 2021 GMC Sierra 2500 Denali w/ Denali Ultimate Package, a Certified 2025 GMC Sierra 2500 Denali w/ Max Trailering Package, and a Used 2015 GMC Sierra 2500 Denali w/ Duramax Plus Package ranging in price from $20,500 to $83,990.

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Used GMC Sierra 2500 for Sale in Spartanburg, SC

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New 2025 GMC Sierra 2500 Denali w/ Denali Reserve Package

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